周敏 副研究员、硕导
研究组室：生物大分子研究室
招生专业：材料科学与工程、材料工程（学硕/专硕）
办公地点：徐汇校区科辅二楼二层C203
E-mail：[email protected]；[email protected]
个人简介：
太阳城集团-太阳城集团官网
，副研究员。2021年博士毕业于华东理工大学材料科学与工程专业，获工学博士学位。2021年至2024年在华东理工大学开展博士后研究，后留校任教。
聚焦于生物医药、生物材料领域抗耐药菌感染研究，通过模拟天然多肽，设计发现抗耐药菌非天然骨架聚多肽。以第一/通讯作者在Nature Microbiology、Science Translational Medicine、Nature Communications（2篇）、Angewandte Chemie International Edition（3篇）、Advanced Functional Materials 等期刊发表论文24篇，研究成果多次被国家自然科学基金委收录为基金资助重要成果。申请PCT专利1件、中国专利5件（2件授权）。入选国家“博新计划”和上海市“超级博士后”，获国家自然科学基金青年项目和博士后科学基金面上一等项目的资助。
课题组研究方向：//suncityjt.net/2019/1209/c4944a102096/page.htm（课题组PI链接）
主持科研项目：
1. 国家自然科学基金青年项目，2024.01-2026.12
2. 国家“博士后创新人才”支持计划，2021.07-2023.06
3. 上海市“超级博士后”激励计划，2021.07-2023.06
4. 中国博士后科学基金面上资助一等项目，2022.09-2024.08
代表性研究论文：
1. Zhou, M.#; Liu, L.#; Cong, Z.; Jiang, W.; Xiao, X.; Xie, J.; Luo, Z.;Chen, S.; Wu, Y.; Shao, N.; Liu, R.* A Dual-Targeting Antifungal is Effective against Multidrug-resistant Human Fungal Pathogens. Nat. Microbiol. 2024, 9, 1325−1339. (入选国家自然科学基金委2024年度报告，Highlighted by BioCentury Innovations, Highlighted by NSFC, ESI 高被引论文, #equal contribution)
2. Xie, J.#; Zhou, M.#; Cong, Z.; Xiao, X.; Liu, L.; Chen, S.; Jiang, W.; Wu, Y.;Liu, R.* A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections. Sci. Transl. Med. 2025, DOI: 10.1126/scitranslmed.adl4870. (正封面)
3. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2-Oxazoline)-Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412−6419. (VIP论文, 内封面, ESI 高被引论文, Highlighted by American Peptide Society)
4. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-β-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020, 59, 7240−7244. (收录为基金委资助重要研究成果)
5. Xie, J.#; Zhou, M.#; Qian, Y.; Cong, Z.; Chen, S.; Zhang,W.; Jiang, W.; Dai, C.; Shao, N.; Ji, Z.; Zou, J.; Xiao, X.; Liu, L.; Chen, M.; Li, J.;Liu, R.* Addressing MRSA Infection and Antibacterial Resistance with Peptoid Polymers. Nat. Commun. 2021, 12, 5898. (Highlighted by BioCentury Innovations, ESI 高被引论文)
6. Wu, T.#; Zhou, M.#; Zou, J.; Chen, Q.; Qian, F.; Kurths, J.; Liu, R.*; Tang, Y.* Few-shot Inverse Design of HDP-Mimicking Polymers against Drug-Resistant Bacteria. Nat. Commun. 2024, 15, 6288.(Highlighted by NSFC)
7. Jiang, W.#; Zhou, M.#; Cong, Z.; Xie, Jia.; Zhang,W.; Chen, S.; Zou, J.; Ji, Z.; Shao, N.; Chen,X.; Li, M.; Liu, R.* Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections. Angew. Chem. Int. Ed. 2022, 134, e202200778. (VIP论文)
8. Xie, J.; Liu, Z.; Zhou, M.*;Luo, Z.; Liu, L.;Xiao, X.; Jiang, W.; Hu, W.; Wu, Y.; Liu, R.* Self-assembled poly(sarcosine) functionalized host defense peptide-mimicking poly-β-peptides for combating drug-resistant fungal infection. Adv. Funct. Mater. 2025, DOI: 10.1002/adfm.20242412.
9. Luo, Z.; Zhao, X.; Zhou, M.*; Zou, J.; Xiao, X.; Liu, L.; Xie, J.; Wu, Y.; Zhang, W.; Liu, R.* Peptide-mimicking Poly(2-oxazoline)s as Adjuvants to Enhance Activities and Antibacterial Spectrum of Polymyxin B. Sci. China. Mater. 2024, 67, 991–999.
10. Cong, Z.; Yan, Z.; Xiao, X.; Liu, L.; Luo, Z.; Zou, J.; Chen, M.; Wu, Y.; Zhou, M.*; Liu, R.* Peptide-Mimicking Poly(2-oxazoline) Displaying Potent Antibacterial and Antibiofilm Activities Against Multidrug-resistant Gram-Positive Pathogenic Bacteria. J. Mater. Sci. Technol. 2025, 214, 233–244.